Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Mechanisms and Management of Retinopathy of Prematurity | New England Journal of Medicine
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We review the cellular and physiological mechanisms responsible for the regulation of blood
flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the …

Retinopathy of prematurity (ROP) affects only premature infants, but as premature births
increase in many areas of the world, ROP has become a leading cause of childhood …

Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Retinopathy of prematurity (ROP) is a common blinding disease in children in the developed
world despite current treatment, and is becoming increasingly prevalent in the developing …

The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

The retina has long been regarded as 'an approachable part of the brain'for investigating
neurosensory processes. Cell biologists are now capitalizing on the accessibility of the …

Objectives: To investigate the role of vascular endothelial growth factor (VEGF) in the
pathogenesis of the first phase of retinopathy of prematurity (ROP) and to examine the …

purpose. To characterize the topography of and the cellular processes that underlie
vascularization of the human retina. methods. The vasculature of human eyes obtained from …