The gut–liver axis and the intersection with the microbiome
In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …
Contribution of the intestinal microbiome and gut barrier to hepatic disorders
DM Chopyk, A Grakoui - Gastroenterology, 2020 - Elsevier
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …
Tight junctions: from simple barriers to multifunctional molecular gates
C Zihni, C Mills, K Matter, MS Balda - Nature reviews Molecular cell …, 2016 - nature.com
Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …
organisms from the outside world. This requires the formation of tight junctions, selective …
IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p, which degrades occludin mRNA
Background & Aims Defects in the epithelial tight junction (TJ) barrier contribute to
development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) …
development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) …
[HTML][HTML] Understanding the effects of gut microbiota dysbiosis on nonalcoholic fatty liver disease and the possible probiotics role: recent updates
Nonalcoholic fatty liver disease (NAFLD) is leading chronic liver syndrome worldwide. Gut
microbiota dysbiosis significantly contributes to the pathogenesis and severity of NAFLD …
microbiota dysbiosis significantly contributes to the pathogenesis and severity of NAFLD …
[HTML][HTML] Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation
A Nicoletti, FR Ponziani, M Biolato… - World journal of …, 2019 - ncbi.nlm.nih.gov
The intimate connection and the strict mutual cooperation between the gut and the liver
realizes a functional entity called gut-liver axis. The integrity of intestinal barrier is crucial for …
realizes a functional entity called gut-liver axis. The integrity of intestinal barrier is crucial for …
Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression
Background & Aims Epithelial tight junctions are compromised in gastrointestinal disease.
Processes that contribute to the resulting barrier loss include endocytic occludin removal …
Processes that contribute to the resulting barrier loss include endocytic occludin removal …
The role of gut microbiota in some liver diseases: from an immunological perspective
L Wang, ZM Cao, LL Zhang, J Li, W Lv - Frontiers in immunology, 2022 - frontiersin.org
Gut microbiota is a microecosystem composed of various microorganisms. It plays an
important role in human metabolism, and its metabolites affect different tissues and organs …
important role in human metabolism, and its metabolites affect different tissues and organs …
Roseburia spp. abundance associates with alcohol consumption in humans and its administration ameliorates alcoholic fatty liver in mice
Although a link between the gut microbiota and alcohol-related liver diseases (ALDs) has
previously been suggested, the causative effects of specific taxa and their functions have not …
previously been suggested, the causative effects of specific taxa and their functions have not …