Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets

EP Rico, DB Rosemberg, KJ Seibt, KM Capiotti… - Neurotoxicology and …, 2011 - Elsevier
Recent advances in neurobiology have emphasized the study of brain structure and function
and its association with numerous pathological and toxicological events. Neurotransmitters …

Zebrafish: An in vivo model for the study of neurological diseases

JD Best, WK Alderton - Neuropsychiatric disease and treatment, 2008 - Taylor & Francis
As the population ages, there is a growing need for effective therapies for the treatment of
neurological diseases. A limited number of therapeutics are currently available to improve …

Y-Maze memory task in zebrafish (Danio rerio): The role of glutamatergic and cholinergic systems on the acquisition and consolidation periods

GP Cognato, JW Bortolotto, AR Blazina… - Neurobiology of learning …, 2012 - Elsevier
The interest in the behavioral features of zebrafish has significantly increased over the past
two decades. However, most available protocols have used longer training periods and …

Long-Term exposure to SSRI citalopram induces neurotoxic effects in zebrafish

X Hong, R Chen, L Zhang, L Yan, J Xin… - … Science & Technology, 2022 - ACS Publications
Residual antidepressants are of increasing concern worldwide, yet critical information on
their long-term neurotoxic impacts on nontarget aquatic animals is lacking. Here, we …

Using zebrafish to assess the impact of drugs on neural development and function

S Guo - Expert opinion on drug discovery, 2009 - Taylor & Francis
Background: Zebrafish is becoming an increasingly attractive model organism for
understanding biology and developing therapeutics, because as a vertebrate, it shares …

Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers

NJ Sylvain, DL Brewster, DW Ali - Neurotoxicology and teratology, 2010 - Elsevier
Children exposed to alcohol in utero have significantly delayed gross and fine motor skills,
as well as deficiencies in reflex development. The reasons that underlie the motor deficits …

Glutamate at the vertebrate neuromuscular junction: from modulation to neurotransmission

MN Colombo, M Francolini - Cells, 2019 - mdpi.com
Although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular
junction of many invertebrates and of vertebrates, glutamate participates in modulating …

Kainate administered to adult zebrafish causes seizures similar to those in rodent models

JM Alfaro, J Ripoll‐Gómez… - European Journal of …, 2011 - Wiley Online Library
Glutamate is the major excitatory neurotransmitter of the central nervous system in
vertebrates. Excitotoxicity, caused by over‐stimulation of the glutamate receptors, is a major …

Glutamate drives the touch response through a rostral loop in the spinal cord of zebrafish embryos

T Pietri, E Manalo, J Ryan… - Developmental …, 2009 - Wiley Online Library
Characterizing connectivity in the spinal cord of zebrafish embryos is not only prerequisite to
understanding the development of locomotion, but is also necessary for maximizing the …

Baicalein 5, 6-dimethyl ether prevents memory deficits in the scopolamine zebrafish model by regulating cholinergic and antioxidant systems

I Brinza, IM Ayoub, OA Eldahshan, L Hritcu - Plants, 2021 - mdpi.com
Baicalein 5, 6-dimethyl ether, a bioactive flavonoid isolated for the first time from Alnus
rugosa, was explored for its capability to relieve memory deficits and decrease oxidative …