[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives

H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

Lipid nanoparticles for nucleic acid delivery: Current perspectives

E Samaridou, J Heyes, P Lutwyche - Advanced drug delivery reviews, 2020 - Elsevier
Nucleic Acid (NA) based therapeutics are poised to disrupt modern medicine and augment
traditional pharmaceutics in a meaningful way. However, a key challenge to advancing NA …

[HTML][HTML] Hyaluronic acid and albumin based nanoparticles for drug delivery

C Lei, XR Liu, QB Chen, Y Li, JL Zhou, LY Zhou… - Journal of Controlled …, 2021 - Elsevier
Albumin, a multifunctional protein, is widely used to prepare nanocarriers. Hyaluronic acid
(HA) is a natural glycosaminoglycan that can specifically bind receptors, such as cluster of …

Drug delivery to the posterior segment of the eye: biopharmaceutic and pharmacokinetic considerations

R Varela-Fernández, V Díaz-Tomé… - Pharmaceutics, 2020 - mdpi.com
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases
(AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the …

[HTML][HTML] Microneedles for advanced ocular drug delivery

K Glover, D Mishra, S Gade, LK Vora, Y Wu… - Advanced drug delivery …, 2023 - Elsevier
In the field of ocular drug delivery, topical delivery remains the most common treatment
option for managing anterior segment diseases, while intraocular injections are the current …

[HTML][HTML] Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

A Mandal, R Bisht, ID Rupenthal, AK Mitra - Journal of Controlled Release, 2017 - Elsevier
Effective intraocular drug delivery poses a major challenge due to the presence of various
elimination mechanisms and physiological barriers that result in low ocular bioavailability …

Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances

S Jacob, AB Nair, J Shah, S Gupta, SHS Boddu… - Pharmaceutics, 2022 - mdpi.com
Due to complicated anatomical and physical properties, targeted drug delivery to ocular
tissues continues to be a key challenge for formulation scientists. Various attempts are …

Microneedle, bio-microneedle and bio-inspired microneedle: A review

G Ma, C Wu - Journal of Controlled Release, 2017 - Elsevier
Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-
scale size endows them with many advantages over hypodermic needles, including …

Hydrogel biomaterials for application in ocular drug delivery

CR Lynch, PPD Kondiah, YE Choonara… - … in bioengineering and …, 2020 - frontiersin.org
There are many challenges involved in ocular drug delivery. These are a result of the many
tissue barriers and defense mechanisms that are present with the eye; such as the cornea …

[HTML][HTML] A review on recent drug delivery systems for posterior segment of eye

K Nayak, M Misra - Biomedicine & pharmacotherapy, 2018 - Elsevier
Eye is the unique sense organ with complex and sophisticated anatomy and physiology.
Being most instrumental for vision, it is secured by varied protective barriers; ranging from …