The fibrinolytic system dissolves fibrin and maintains vascular patency. Recent advances in
imaging analyses allowed visualization of the spatiotemporal regulatory mechanism of …

The association between coagulation and cancer development has been observed for
centuries. However, the connection between inflammation and malignancy is also well …

Since an extensive genome research has started, basic principle “one gene—one protein—
one function” was significantly revised. Many proteins with more than one function were …

Background The extra-intestinal effects of probiotics for preventing allergic diseases are well
known. However, the probiotic components that interact with host target molecules and have …

Regulated cellular metabolism has emerged as a fundamental process controlling
macrophage functions, but there is still much to uncover about the precise signaling …

Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in
nerve cells around the adrenal gland, although other locations are possible …

Abstract Mycobacterium tuberculosis (M. tb), the major causative agent of tuberculosis, has
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …

At the beginning of the twentieth century, discoveries in cancer research began to elucidate
the idiosyncratic metabolic proclivities of tumor cells. Investigators postulated that revealing …

Genetic networks are surprisingly robust to perturbations caused by new mutations. This
robustness is conferred in part by compensation for loss of a gene's activity by genes with …

Moonlighting and multitasking proteins refer to proteins with two or more functions
performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) …