8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
In pathophysiology, reactive oxygen species control diverse cellular phenotypes by
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …
DNA logic circuits for cancer theranostics
Cancer diagnosis and therapeutics (theranostics) based on the tumor microenvironment
(TME) and biomarkers has been an emerging approach for precision medicine. DNA …
(TME) and biomarkers has been an emerging approach for precision medicine. DNA …
Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon
The in vivo optical imaging of RNA biomarkers of inflammation is hindered by low signal-to-
background ratios, owing to non-specific signal amplification in healthy tissues. Here we …
background ratios, owing to non-specific signal amplification in healthy tissues. Here we …
Development of a DNAzyme walker for the detection of APE1 in living cancer cells
DNAzyme walker technology is a compelling option for bioanalytical and drug delivery
applications. While nucleic acid and protein targets have been used to activate DNAzyme …
applications. While nucleic acid and protein targets have been used to activate DNAzyme …
Organelle‐Specific Photoactivation of DNA Nanosensors for Precise Profiling of Subcellular Enzymatic Activity
Understanding of the functions of enzymes in diverse cellular processes is important, but the
design of sensors with controllable localization for in situ imaging of subcellular levels of …
design of sensors with controllable localization for in situ imaging of subcellular levels of …
[HTML][HTML] Not breathing is not an option: How to deal with oxidative DNA damage
E Markkanen - DNA repair, 2017 - Elsevier
Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …
implicated in the pathogenesis of a wide variety of diseases, including cancer and …
The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease
RA Caston, S Gampala, L Armstrong… - Drug Discovery …, 2021 - Elsevier
Highlights•APE1 protein repairs small base lesions in the DNA base excision repair
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …
Endogenous enzyme-powered DNA nanomotor operating in living cells for microRNA imaging
T Li, M Sun, Q Zhou, P Liang, T Huang, M Guo… - Analytical …, 2023 - ACS Publications
Accurate and specific imaging of low-abundance microRNA (miRNA) in living cells is
extremely important for disease diagnosis and monitoring of disease progression. DNA …
extremely important for disease diagnosis and monitoring of disease progression. DNA …
Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown
New strategies for cancer immunotherapy are needed since most solid tumors do not
respond to current approaches. Here we used epithelial cell adhesion molecule EpCAM (a …
respond to current approaches. Here we used epithelial cell adhesion molecule EpCAM (a …
NF-κB in biology and targeted therapy: new insights and translational implications
Q Guo, Y Jin, X Chen, X Ye, X Shen, M Lin… - … and Targeted Therapy, 2024 - nature.com
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …
identified as a pivotal pathway in mediating inflammatory responses. However, with …