This work discusses active and passive electrical properties of transverse (T-) tubules in
ventricular cardiomyocytes to understand the physiological roles of T-tubules. T-tubules are …

Background: Mutations in the gene encoding the cardiac voltage-gated sodium channel
Nav1. 5 cause various cardiac arrhythmias. This variety may arise from different …

T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a
large surface for ion channels and signaling proteins, thereby supporting excitation …

The recent development of nanomanipulation tools such as optical tweezers or atomic force
microscopes has paved the way to the exploration of the mechanical properties of biological …

Calcium mishandling and mitochondrial dysfunction have been increasingly recognized as
significant factors involved in the progression procedure of cardiomyopathy. Ca2+ …

Mutations in the gene encoding the sodium channel Nav1. 5 cause various cardiac
arrhythmias. This variety may arise from different determinants of Nav1. 5 expression …