Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer
cells with non-malignant cells of the tumor microenvironment. Major players in the tumor …

Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent
years. ITH describes the cellular variation that enables tumour evolution, including tumour …

Background & Aims Transforming growth factor-b (TGFb) plays pleiotropic roles in
pancreatic cancer, including promoting metastasis, attenuating CD8 T-cell activation, and …

Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …

Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive type of
pancreatic cancer and has abysmal survival rates. In the past two decades …

Pancreatic cancer is highly lethal. New diagnostic and treatment modalities are desperately
needed. We report here that an expanded porphyrin, cyclo [8] pyrrole (CP), with a high …

Simple Summary The progression of pancreatic cancer (PDAC) involves a series of events
transforming the phenotype of cancer cells, namely epithelial-to-mesenchymal transition …

The transforming growth factor (TGF)-β superfamily has important physiologic roles and is
dysregulated in many pathologic processes, including pancreatic cancer. Pancreatic cancer …