Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Acute kidney injury (AKI), a major public health problem associated with high mortality and
increased risk of progression towards end-stage renal disease, is characterized by the …

Acute kidney injury is often the result of ischemia reperfusion injury, which leads to activation
of coagulation and inflammation, resulting in necrosis of renal tubular epithelial cells …

This review collects evidence about immune and inflammatory functions of platelets from a
clinician's point of view. A focus on clinically relevant immune functions aims at stimulating …

The prevention of allograft transplant rejection by inhibition of the CD40/CD40L
costimulatory pathway has been described in several species. We searched pubmed for …

Background Tumor necrosis factor-α (TNF-α) is a potent proinflammatory cytokine involved
in a variety of disease pathologies, including ischemia/reperfusion (I/R) injuries in …

Innate immune activation as a consequence of ischemia–reperfusion injury may
compromise engraftment of the intestine. More dedicated research is required to further …

Background Previous study from this lab has discerned oxidative, nitrosative stress and their
relationship with cytokines contributing to the severity of sepsis and organ dysfunction …

Ischemia–reperfusion (IR) injury is a common complication of a variety of cardiovascular
diseases, including ischemic stroke and myocardial infarction (MI). While timely re …

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency or failure caused by
various factors inside and outside the lungs. ALI is associated with high morbidity and a poor …