Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …

Transcriptional control is a highly dynamic process that changes rapidly in response to
various cellular and extracellular cues, making it difficult to define the mechanism of …

The establishment of de novo chromatin accessibility in lymphoid progenitors requires the
“pioneering” function of transcription factor (TF) early B cell factor 1 (EBF1), which binds to …

Combinatorial signaling by proinflammatory cytokines synergizes to exacerbate toxicity to
cells and tissue injury during acute infections. To explore synergism at the gene regulatory …

Transcriptional dysregulation is a hallmark of diffuse large B cell lymphoma (DLBCL), as
transcriptional regulators are frequently mutated. However, our mechanistic understanding …

Isochromosomes are mirror-imaged chromosomes with simultaneous duplication and
deletion of genetic material which may contain two centromeres to create isodicentric …

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging
therapeutic target that is overexpressed in most castration resistant prostate cancers and …

Genetic models suggested that SMARCA5 was required for DNA templated events including
transcription, DNA replication and DNA repair. We engineered a degron tag into the …

Gene expression networks are perturbed in every human malignancy. One common way
that this occurs is through chromosomal translocation, such as t (8; 21) or t (2; 13), which …

Transcriptional dysregulation is a key step in oncogenesis, but our understanding of
transcriptional control has relied on genetic approaches that are slow and allow for …