Oximes: Novel therapeutics with anticancer and anti-inflammatory potential

IA Schepetkin, MB Plotnikov, AI Khlebnikov… - Biomolecules, 2021 - mdpi.com
Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship

H Wang, Z Wang, C Wei, J Wang, Y Xu, G Bai… - European Journal of …, 2021 - Elsevier
Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional
Chinese medicine herbal formulas used for the therapy of chronic myelocytic leukemia in …

Meisoindigo protects against focal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage …

Y Ye, T Jin, X Zhang, Z Zeng, B Ye, J Wang… - Frontiers in cellular …, 2019 - frontiersin.org
Ischemic stroke is a devastating disease with long-term disability. However, the
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …

Indole-based small molecules as potential therapeutic agents for the treatment of fibrosis

R Qin, Q Zhao, B Han, HP Zhu, C Peng… - Frontiers in …, 2022 - frontiersin.org
Indole alkaloids are widely distributed in nature and have been particularly studied because
of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and …

Indole alkaloids with potential anticancer activity

D Xu, Z Xu - Current topics in medicinal chemistry, 2020 - ingentaconnect.com
Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically
active compounds. Indole alkaloids have the potential to exert anticancer activity via various …

Indirubin and indirubin derivatives for counteracting proliferative diseases

T Blažević, EH Heiss, AG Atanasov… - Evidence‐Based …, 2015 - Wiley Online Library
Indirubin is the active component of Danggui Longhui Wan, a traditional Chinese medicine
formulation. The encouraging clinical results from the 1980s obtained in chronic myelocytic …

Are the traditional medical uses of Muricidae molluscs substantiated by their pharmacological properties and bioactive compounds?

K Benkendorff, D Rudd, B Devi Nongmaithem, L Liu… - Marine drugs, 2015 - mdpi.com
Marine molluscs from the family Muricidae hold great potential for development as a source
of therapeutically useful compounds. Traditionally known for the production of the ancient …

Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential

Y Ren, K DeRose, L Li, JC Gallucci, J Yu… - Bioorganic & Medicinal …, 2023 - Elsevier
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been
used clinically for the prevention and treatment of cerebrovascular disorders and …

[HTML][HTML] Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation

Q Wang, J Yu, Y Hu, X Chen, L Zhang, T Pan… - Biomedicine & …, 2020 - Elsevier
Background and objective Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial
lung disease with a poor prognosis. Indirubin, a compound obtained from indigo-bearing …

Transdermal delivery of indirubin-loaded microemulsion gel: preparation, characterization and anti-psoriatic activity

E He, H Li, X Li, X Wu, K Lei, Y Diao - International journal of molecular …, 2022 - mdpi.com
Psoriasis is an immune disease caused by rapid and incomplete differentiation of skin basal
cells. Natural products such as indirubin have historically served as excellent sources for the …