Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …

Selected reaction monitoring (SRM) is a targeted mass spectrometry technique that is
emerging in the field of proteomics as a complement to untargeted shotgun methods. SRM is …

MSstats is an R package for statistical relative quantification of proteins and peptides in
mass spectrometry-based proteomics. Version 2.0 of MSstats supports label-free and label …

Proteins constitute a key class of molecular components that perform essential biochemical
reactions in living cells. Whether the aim is to extensively characterize a given protein or to …

Mitochondrial respiration and tricarboxylic acid (TCA) cycle activity are required during salt
stress in plants to provide ATP and reductants for adaptive processes such as ion exclusion …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Protein complexes and protein interaction networks are essential mediators of most
biological functions. Complexes supporting transient functions such as signal transduction …

A major goal of proteomics research is the accurate and sensitive identification and
quantification of a broad range of proteins within a sample. Data-independent acquisition …

To design a robust quantitative proteomics study, an understanding of both the inherent
heterogeneity of the biological samples being studied as well as the technical variability of …

Targeted mass spectrometry by selected reaction monitoring (S/MRM) has proven to be a
suitable technique for the consistent and reproducible quantification of proteins across …