In the new WHO 2021 Classification of CNS Tumors the chapter “Circumscribed astrocytic
gliomas, glioneuronal and neuronal tumors” encompasses several different rare tumor …

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …

Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder affecting almost all
organs with no sex predominance. TSC has an autosomal-dominant inheritance and is …

Introduction Subependymal ependymal giant cell astrocytomas (SEGAs) occur almost
exclusively in the setting of tuberous sclerosis (TSC). They are low-grade gliomas which …

Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate numerous
cell types. The uncoupling of mRNA transcript availability and translation occurs during the …

The aim of this EMINENTS prospective, single-center, open-label, single-arm study was to
evaluate the cumulative efficacy and safety of reduced doses of everolimus (maintenance …

Genetic syndromes which develop one or more nervous system (NS) tumors as one of the
manifestations can be grouped under the umbrella term of NS tumor predisposition …

Introduction Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder
affecting multiple systems, due to inactivating mutations of TSC1 or TSC2 mTOR pathway …

Introduction, Tuberous sclerosis complex (TSC) is an autosomal-dominant disorder caused
by mutations inactivating TSC1 or TSC2 genes and characterized by the presence of tumors …

Introduction Surgical removal has been the historical treatment for subependymal giant-cell
astrocytoma (SEGA) in tuberous sclerosis complex (TSC) patients. In the past decade …