New insights in cardiac β-adrenergic signaling during heart failure and aging
Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …
decreasing their survival and overall quality of life. In fact, despite the improvements in …
Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation
MY Rincon, T VandenDriessche… - Cardiovascular …, 2015 - academic.oup.com
Gene therapy is a promising modality for the treatment of inherited and acquired
cardiovascular diseases. The identification of the molecular pathways involved in the …
cardiovascular diseases. The identification of the molecular pathways involved in the …
Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ
H He, Y Luo, Y Qiao, Z Zhang, D Yin, J Yao, J You… - Food & Function, 2018 - pubs.rsc.org
Doxorubicin (Dox) induces cardiotoxicity, thereby limiting its clinical application for
chemotherapy of cancer. The mechanism of cardiotoxicity includes the production of excess …
chemotherapy of cancer. The mechanism of cardiotoxicity includes the production of excess …
β-adrenergic receptor responsiveness in aging heart and clinical implications
Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle
inotropic reserve related to increased vascular afterload, arterial-ventricular load …
inotropic reserve related to increased vascular afterload, arterial-ventricular load …
Effects of exercise on cardiovascular performance in the elderly
C Vigorito, F Giallauria - Frontiers in physiology, 2014 - frontiersin.org
Progressive aging induces several structural and functional alterations in the cardiovascular
system, among whom particularly important are a reduced number of myocardial cells and …
system, among whom particularly important are a reduced number of myocardial cells and …
Adrenergic signaling and oxidative stress: a role for sirtuins?
The adrenergic system plays a central role in stress signaling and stress is often associated
with increased production of ROS. However, ROS overproduction generates oxidative …
with increased production of ROS. However, ROS overproduction generates oxidative …
Growth hormone deficiency is associated with worse cardiac function, physical performance, and outcome in chronic heart failure: insights from the TOS CA. GHD …
Background Although mounting evidence supports the concept that growth hormone (GH)
deficiency (GHD) affects cardiovascular function, no study has systematically investigated its …
deficiency (GHD) affects cardiovascular function, no study has systematically investigated its …
Adrenoreceptors and nitric oxide in the cardiovascular system
Nitric Oxide (NO) is a small molecule that continues to attract much attention from the
scientific community. Since its discovery, it has been evident that NO has a crucial role in the …
scientific community. Since its discovery, it has been evident that NO has a crucial role in the …
Effects of exercise training on cardiovascular adrenergic system
D Leosco, V Parisi, GD Femminella… - Frontiers in …, 2013 - frontiersin.org
In heart failure (HF), exercise has been shown to modulate cardiac sympathetic
hyperactivation which is one of the earliest features of neurohormonal derangement in this …
hyperactivation which is one of the earliest features of neurohormonal derangement in this …
Long-term caloric restriction improves cardiac function, remodeling, adrenergic responsiveness, and sympathetic innervation in a model of postischemic heart failure
Background: Caloric restriction (CR) has been described to have cardioprotective effects
and improve functional outcomes in animal models and humans. Chronic ischemic heart …
and improve functional outcomes in animal models and humans. Chronic ischemic heart …