It is estimated that about 10% of the drugs approved worldwide can be classified as
prodrugs. Prodrugs, which have no or poor biological activity, are chemically modified …

Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

Gemcitabine is a nucleoside analogue commonly used in cancer therapy but with limited
efficacy due to a high susceptibility to cancer cell resistance. The addition of a …

Peptide transport is currently a prominent topic in membrane research. The transport
proteins involved are under intense investigation because of their physiological importance …

Prodrugs are biologically inactive agents that upon biotransformation in vivo result in active
drug molecules. Since prodrugs might alter the tissue distribution, efficacy and the toxicity of …

Nucleoside analogues are widely used for the treatment of antiviral infections and
anticancer chemotherapy. However, many nucleoside analogues suffer from poor oral …

Although drugs currently used for the various types of diseases (eg, antiparasitic, antiviral,
antibacterial, etc.) are effective, they present several undesirable pharmacological and …

Highlights•Recent crystal structures reveal insights into ligand promiscuity within the POT
family.•Selectivity pockets play important roles in peptide recognition and …

Intestinal inflammation is characterized by epithelial disruption, leading to loss of barrier
function and the recruitment of immune cells, including neutrophils. Although the …

The human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of
dipeptides, tripeptides, and many peptidomimetic drugs. In this study, a large number of …