For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but
recent results have shown that they could become a reality. Convincing data generated with …

Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

In Alzheimer's disease, amyloid-beta (Aβ) triggers the trans-synaptic spread of tau
pathology, and aberrant synaptic activity has been shown to promote tau spreading. Aβ …

Synaptic dysfunction and degeneration is likely the key pathophysiology for the progression
of cognitive decline in various dementia disorders. Synaptic status can be monitored by …

Importance Factors associated with synapse loss beyond amyloid-β plaques and
neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in …

(1) Background: Neurogranin is a post-synaptic protein expressed in the neurons of the
hippocampus and cerebral cortex. It has been recently proposed as a promising biomarker …

Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …

Introduction Synaptic dysfunction and degeneration is one of the earliest events in
Alzheimer's disease (AD) and the best correlate of cognitive decline. Thus, identification and …

Background and Objectives To determine whether CSF synaptic biomarkers are altered in
the early preclinical stage of the Alzheimer continuum and associated with Alzheimer …