Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Functional loss often occurs in many body systems (eg, endocrine, cognitive, motor) with the
passage of years, but there is great individual variation in the degree of compromise shown …

We examined age-, sex-, and hemisphere-related differences in the cerebral cortex.
Volumes of the cerebral hemispheres and 13 regions of interest (ROIs) were measured on …

Recent epidemiological and clinical data suggest that persons with low folic acid levels and
elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the …

Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …

Aging and increased amyloid burden are major risk factors for cognitive diseases such as
Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we …

We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor
dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were …

The morphological changes that occur during normal brain aging are not well understood.
This study used modern stereology to assess the effects of age and gender on total numbers …

We comparedthe characteristics of the visually evoked hemodynamic response (HDR) in
groups of young and elderly adults. Checkerboard stimuli were presented for 500 ms either …

Volumes of thalamus, pons, cortical gray matter, and white matter were derived from MR
brain images of healthy men and women spanning the adult age range in order to delineate …