G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a member of G-protein-coupled
receptor (GPCR) superfamily. High levels of TGR5 mRNA were detected in several tissues …

Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction.
Although insulin resistance is assumed to be a main pathophysiological feature of the …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Background Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but
normal-weight people. However, we have limited knowledge of how to prevent T2DM in …

Type 2 diabetes is characterized by insulin resistance and a gradual loss of pancreatic beta
cell mass and function,. Currently, there are no therapies proven to prevent beta cell loss …

This study aimed to evaluate the role of the triglyceride (triacylglycerol) glucose (TyG) index
in predicting and mediating the development of cardiovascular disease (CVD). This cohort …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Beta cell failure is a central feature of type 2 diabetes (T2D), but the molecular
underpinnings of the process remain only partly understood. It has been suggested that beta …

Metabolic homeostasis of fatty acids is complex and well-regulated in all organisms. The
biosynthesis of saturated fatty acids (SFA) in mammals provides substrates for β-oxidation …

The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases
with ageing. T2D generally results from progressive impairment of the pancreatic islets to …