Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

ANIMAL somatic cell DNA is characterized by a bimodal pattern of methylation: tissue-
specific genes are methylated in most cell types whereas housekeeping genes have 5 …

INHIBITORS of the human immunodeficiency virus type 1 (HIV-1) protease have entered
clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 …

▪ Abstract One strand of cellular DNA is generated as RNA-initiated discontinuous segments
called Okazaki fragments that later are joined. The RNA terminated region is displaced into …

HUMANS with a defect in the XPG protein suffer from xeroderma pigmentosum (XP)
resulting from an inability to perform DNA nucleotide excision repair properly1–4. Here we …

Eukaryotic cells have multiple mechanisms for repairing damaged DNA. 06-methylguanine-
DNA methyltransferase directly reverses some simple alkylation adducts. However, most …

Fig. 2. Molecular mechanisms of nucleotide excision repair in humans and in E. co'i.(i) Initial
damage recognition is ATP-independent.(ii) Distortion of the helix by molecular …

Publisher Summary DNA damage is a common occurrence that compromises the functional
integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with …