Molecular biomarkers in cancer

VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

Colorectal liver metastasis: molecular mechanism and interventional therapy

H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

[HTML][HTML] Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

A Thakur, DC Parra, P Motallebnejad, M Brocchi… - Bioactive materials, 2022 - Elsevier
Cancer is a deadly disease that is globally and consistently one of the leading causes of
mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy …

Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer

KA Preethi, SC Selvakumar, K Ross, S Jayaraman… - Molecular Cancer, 2022 - Springer
Background Detecting cancer at an early stage before clinical manifestation could be an
effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers …

Overview of MicroRNAs as diagnostic and prognostic biomarkers for high-incidence cancers in 2021

C Zhang, C Sun, Y Zhao, Q Wang, J Guo, B Ye… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) about 22 nucleotides in size,
which play an important role in gene regulation and are involved in almost all major cellular …

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

K He, Z Wang, M Luo, B Li, N Ding, L Li, B He… - Journal of Translational …, 2023 - Springer
Distant metastasis remains a leading cause of mortality among patients with colorectal
cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific …

Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A

W Shi, Y Liu, X Qiu, L Yang, G Lin - Carcinogenesis, 2023 - academic.oup.com
Colorectal cancer (CRC) is the second leading cause of cancer-induced death in the world.
Cancer-associated fibroblasts (CAFs) released exosomes that contributed to cancer …

MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

E Martino, N D'Onofrio, C Anastasio, M Abate… - … Therapy-Nucleic Acids, 2023 - cell.com
Micro-RNAs (miRNAs) control gene expression at the post-transcriptional level and are
widely involved in carcinogenesis, playing a role as both oncogenes and tumor …

Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer

D Zhong, Z Wang, Z Ye, Y Wang, X Cai - Molecular Cancer, 2024 - Springer
Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor
and has a significant impact on mortality rates. Nevertheless, the swift advancement of …

Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review

Z Fang, Y Ding, Z Xue, P Li, J Li, F Li - Discover Oncology, 2022 - Springer
Exosomes can be released by a variety of cells and participate in intercellular
communication in many physiological processes in the body. They can be used as carriers …