Viral hepatitis and liver cancer: the case of hepatitis C

M Levrero - Oncogene, 2006 - nature.com
Chronic infection with the hepatitis C virus (HCV) is a major risk factor for the development of
hepatocellular carcinoma (HCC) worldwide. The pathogenesis of HCC in HCV infection has …

The role of cytokines in hepatocellular carcinoma

A Budhu, XW Wang - Journal of leukocyte biology, 2006 - academic.oup.com
Hepatocellular carcinoma (HCC) is a frequent malignancy worldwide with a high rate of
metastasis. The hepatitis B and C viruses are considered major etiological factors …

Viral hepatocarcinogenesis

WL Tsai, RT Chung - Oncogene, 2010 - nature.com
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading
cause of cancer death worldwide. Despite recent advances in the diagnosis and treatment of …

Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

DR McGivern, SM Lemon - Oncogene, 2011 - nature.com
The development of hepatocellular carcinoma (HCC) in persons who are persistently
infected with hepatitis C virus (HCV) is a growing problem worldwide. Current antiviral …

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

K Machida, H Tsukamoto… - Proceedings of the …, 2009 - National Acad Sciences
Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer
caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy …

Hepatitis C virus and hepatocellular carcinoma: when the host loses its grip

K Goto, AA Roca Suarez, F Wrensch… - International journal of …, 2020 - mdpi.com
Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma
(HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained …

Pathogenesis of hepatitis C—associated hepatocellular carcinoma

TJ Liang, T Heller - Gastroenterology, 2004 - Elsevier
Epidemiologic, clinical, and virologic data have shown a close association between chronic
infection with hepatitis C virus (HCV) and the development of hepatocellular carcinoma …

Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges

MJ Bouchard, S Navas-Martin - Cancer letters, 2011 - Elsevier
Worldwide, hepatocellular carcinoma (HCC) is one of the most common cancers. It is
thought that 80% of hepatocellular carcinomas are linked to chronic infections with the …

TLR4 signaling via NANOG cooperates with STAT3 to activate Twist1 and promote formation of tumor-initiating stem-like cells in livers of mice

DBU Kumar, CL Chen, JC Liu, DE Feldman, LS Sher… - Gastroenterology, 2016 - Elsevier
Background & Aims Obesity and alcohol consumption contribute to steatohepatitis, which
increases the risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs) …

Animal models for hepatitis C

E Billerbeck, Y De Jong, M Dorner… - Hepatitis C virus: from …, 2013 - Springer
Hepatitis C remains a global epidemic. Approximately 3% of the world's population suffers
from chronic hepatitis C, which is caused by hepatitis C virus (HCV)—a positive sense …