Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …

The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell
that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms …

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Nephropathy is a major complication of diabetes. Alterations of mesangial cells have
traditionally been the focus of research in deciphering molecular mechanisms of diabetic …

Transforming growth factor beta (TGF-β) has been recognized as an important mediator in
the genesis of chronic kidney diseases (CKD), which are characterized by the accumulation …

OBJECTIVE We investigated the role of cytochrome P450 of the 4A family (CYP4A), its
metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and …