[HTML][HTML] Exosomes as a new frontier of cancer liquid biopsy

D Yu, Y Li, M Wang, J Gu, W Xu, H Cai, X Fang… - Molecular cancer, 2022 - Springer
Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

A DNA-based hydrogel for exosome separation and biomedical applications

J Tang, X Jia, Q Li, Z Cui, A Liang… - Proceedings of the …, 2023 - National Acad Sciences
Exosomes (EXOs) have been proven as biomarkers for disease diagnosis and agents for
therapeutics. Great challenge remains in the separation of EXOs with high-purity and low …

Molecular characterization of exosomes for subtype-based diagnosis of breast cancer

Y Cao, X Yu, T Zeng, Z Fu, Y Zhao, B Nie… - Journal of the …, 2022 - ACS Publications
Breast cancer is very heterogeneous and the most frequently diagnosed cancer worldwide,
and precise therapy targeting specific subtypes may improve the survival rates of breast …

Machine learning-based label-free SERS profiling of exosomes for accurate fuzzy diagnosis of cancer and dynamic monitoring of drug therapeutic processes

X Diao, X Li, S Hou, H Li, G Qi, Y Jin - Analytical Chemistry, 2023 - ACS Publications
Exosomes are a class of extracellular vesicles secreted by cells, which can be used as
promising noninvasive biomarkers for the early diagnosis and treatment of diseases …

Engineering a second‐order DNA logic‐gated nanorobot to sense and release on live cell membranes for multiplexed diagnosis and synergistic therapy

D Wang, S Li, Z Zhao, X Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Tumor biomarker‐based theranostics have achieved broad interest and success in recent
years. However, single biomarker‐based recognition can cause false‐positive feedback …

One‐Step Thermophoretic AND Gate Operation on Extracellular Vesicles Improves Diagnosis of Prostate Cancer

J Deng, S Zhao, J Li, Y Cheng, C Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
Circulating extracellular vesicles (EVs) have emerged as a valuable source of cancer
biomarkers. However, the high degree of EV heterogeneity and the complexity of clinical …

Activating a DNA nanomachine via computation across cancer cell membranes for precise therapy of solid tumors

Y Zhang, W Chen, Y Fang, X Zhang… - Journal of the American …, 2021 - ACS Publications
Taking advantage of cancer cells' endogenous characters, the responsive activation of DNA
nanomachines has achieved great success in tumor therapy. Combining with extra stimuli …

Dual-aptamer-assisted ratiometric SERS biosensor for ultrasensitive and precise identification of breast cancer exosomes

Q Zhang, R Ma, Y Zhang, J Zhao, Y Wang, Z Xu - ACS sensors, 2023 - ACS Publications
Due to the heterogeneity of breast cancer, its early accurate diagnosis remains a challenge.
Exosomes carry abundant genetic materials and proteins and are ideal biomarkers for early …

Functional DNA sensors integrated with nucleic acid signal amplification strategies for non-nucleic acid targets detection

Y Zhu, J Wu, Q Zhou - Biosensors and Bioelectronics, 2023 - Elsevier
In addition to carrying and transmitting genetic material, some DNA molecules have specific
binding ability or catalytic function. DNA with this special function is collectively referred to as …