With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Cancer cells frequently display fundamentally altered cellular metabolism, which provides
the biochemical foundation and directly contributes to tumorigenicity and malignancy …

The development of immune checkpoint inhibitors (ICI) marks an important breakthrough of
cancer therapies in the past years. However, only a limited fraction of patients benefit from …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Dysregulation of fatty acid metabolism is recognized as a component of malignant
transformation in many different cancers, including breast; yet the potential for targeting this …

Simple Summary Cancer cells directly control nutrient uptake and utilization in a different
manner from that of normal cells. These metabolic changes drive growth, proliferation of …

Failure to reorganize the endoplasmic reticulum (ER) in mitosis results in chromosome
missegregation. Here, we show that accurate chromosome segregation in human cells …

Bidirectional interactions between cancer cells and their microenvironment govern tumor
progression. Among the stromal cells in this microenvironment, adipocytes have been …

RNA sequencing studies with complex designs and transcript-resolution analyses involve
multiple hypotheses per gene; however, conventional approaches fail to control the false …