The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …

This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …

Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

Mixed-phenotype acute leukemia (MPAL) encompasses a heterogeneous group of rare
leukemias in which assigning a single lineage of origin is not possible. A variety of different …

Despite attempts to improve the definitions of ambiguous lineage leukemia (ALAL) during
the last 2 decades, general therapy recommendations are missing. Herein, we report a large …

Mixed-phenotype acute leukemia (MPAL) is a heterogeneous category in the World Health
Organization classification that comprises acute leukemias with discrete admixed …

The International Consensus Classification of Myeloid and Lymphoid Neoplasms is the
result of the findings of a clinical advisory committee (CAC) meeting with involvement by an …

Highlights•Whole exome sequencing identified a spectrum of mutations in patients with
mixed-phenotype acute leukemia (MPAL).•DNMT3A was mutated in 33% of adult patients …

Mixed-phenotype acute leukemia (MPAL) comprises a heterogenous group of leukemias
that are genetically, immunophenotypically, and clinically, diverse. Given the rarity of the …

Objectives This session of the Society for Hematopathology/European Association for
Haematopathology Workshop focused on acute leukemias of ambiguous origin. Methods …