Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …

Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …

Human peroxisome biogenesis disorders (PBDs) are a heterogeneous group of autosomal
recessive disorders comprised of two clinically distinct subtypes: the Zellweger syndrome …

Peroxisomes are single-membrane organelles essential for cell metabolism including the β-
oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis …

ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane
proteins, and are present in almost all living organisms from eubacteria to mammals. They …

Peroxisomes contribute to several crucial metabolic processes such as β-oxidation of fatty
acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species …

More than half a century of research on peroxisomes has revealed unique features of this
ubiquitous subcellular organelle, which have often been in disagreement with existing …

The biogenesis of peroxisomal matrix and membrane proteins is substantially different from
the biogenesis of proteins of other subcellular compartments, such as mitochondria and …

We show that a comprehensive set of 16 peroxisomal membrane proteins (PMPs)
encompassing all types of membrane topologies first target to the endoplasmic reticulum …