[HTML][HTML] mTOR substrate phosphorylation in growth control
The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …
serine/threonine protein kinase that plays a central role in regulating cell growth and …
The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
J Wang, L Chen, P Qiang - Cancer cell international, 2021 - Springer
The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is
an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 …
an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 …
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Abstract N 6-methyladenosine (m6A) is the most prevalent modification in eukaryotic
messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain …
messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain …
[HTML][HTML] Molecular neurobiology of mTOR
K Switon, K Kotulska, A Janusz-Kaminska… - Neuroscience, 2017 - Elsevier
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …
controls several important aspects of mammalian cell function. mTOR activity is modulated …
[HTML][HTML] The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer
D Ramesh-Kumar, S Guil - Seminars in Cancer Biology, 2022 - Elsevier
RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …
mechanisms to modulate the transcriptional output and respond to changing cellular …
The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
X Wang, Y Ji, P Feng, R Liu, G Li, J Zheng… - Advanced …, 2021 - Wiley Online Library
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue
microenvironment. Currently, little is known about how the intrinsic regulators modulate …
microenvironment. Currently, little is known about how the intrinsic regulators modulate …
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide
Emerging studies have linked the ribosome to more selective control of gene regulation.
However, an outstanding question is whether ribosome heterogeneity at the level of core …
However, an outstanding question is whether ribosome heterogeneity at the level of core …
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells
M Janiszewska, ML Suvà, N Riggi… - Genes & …, 2012 - genesdev.cshlp.org
Growth of numerous cancer types is believed to be driven by a subpopulation of poorly
differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for …
differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for …
[HTML][HTML] The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer
M Lederer, N Bley, C Schleifer, S Hüttelmaier - Seminars in cancer biology, 2014 - Elsevier
The post-transcriptional control of gene expression mediated by RNA-binding proteins
(RBPs), long non-coding RNAs (lncRNAs) as well as miRNAs is essential to determine …
(RBPs), long non-coding RNAs (lncRNAs) as well as miRNAs is essential to determine …