Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Staphylococcal trafficking and infection—from 'nose to gut'and back

EJM Raineri, D Altulea… - FEMS microbiology …, 2022 - academic.oup.com
Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

L Tuchscherr, B Löffler, RA Proctor - Frontiers in Microbiology, 2020 - frontiersin.org
Staphylococcus aureus is able to survive within host cells by switching its phenotype to the
small-colony variant (SCV) phenotype. The emergence of SCVs is associated with the …

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

SG Giulieri, R Guérillot, S Duchene, A Hachani… - Elife, 2022 - elifesciences.org
During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …

Intracellular Staphylococcus aureus and host cell death pathways

YM Soe, S Bedoui, TP Stinear… - Cellular …, 2021 - Wiley Online Library
Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent.
Although S. aureus and humans may have co‐evolved to the point of commensalism, the …

Efficient microbial colony growth dynamics quantification with ColTapp, an automated image analysis application

J Bär, M Boumasmoud, RD Kouyos, AS Zinkernagel… - Scientific reports, 2020 - nature.com
Populations of genetically identical bacteria are phenotypically heterogeneous, giving rise to
population functionalities that would not be possible in homogeneous populations. For …

Surface engineering of magnetic peroxidase mimic using bacteriophage for high-sensitivity/specificity colorimetric determination of Staphylococcus aureus in food

W Zhou, H Wen, G Hao, YS Zhang, J Yang, L Gao… - Food Chemistry, 2023 - Elsevier
Herein, we proposed surface engineering of magnetic peroxidase mimic using
bacteriophage by electrostatic interaction to prepare bacteriophage SapYZU15 modified Fe …

Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells

HK Alexander, RC MacLean - Proceedings of the National …, 2020 - National Acad Sciences
A better understanding of how antibiotic exposure impacts the evolution of resistance in
bacterial populations is crucial for designing more sustainable treatment strategies. The …

Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …

The Role of hlb-Converting Bacteriophages in Staphylococcus aureus Host Adaption

C Rohmer, C Wolz - Microbial Physiology, 2021 - karger.com
As an opportunistic pathogen of humans and animals, Staphylococcus aureus
asymptomatically colonizes the nasal cavity but is also a leading cause of life-threatening …