A brief introduction to chemical reaction optimization

CJ Taylor, A Pomberger, KC Felton, R Grainger… - Chemical …, 2023 - ACS Publications
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

Self-driving laboratories for chemistry and materials science

G Tom, SP Schmid, SG Baird, Y Cao, K Darvish… - Chemical …, 2024 - ACS Publications
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Carboxylic acids as adaptive functional groups in metallaphotoredox catalysis

SB Beil, TQ Chen, NE Intermaggio… - Accounts of chemical …, 2022 - ACS Publications
Conspectus The development of palladium-catalyzed cross-coupling methods for the
activation of C (sp2)–Br bonds facilitated access to arene-rich molecules, enabling a …

Photocatalysis in the life science industry

L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Bayesian reaction optimization as a tool for chemical synthesis

BJ Shields, J Stevens, J Li, M Parasram, F Damani… - Nature, 2021 - nature.com
Reaction optimization is fundamental to synthetic chemistry, from optimizing the yield of
industrial processes to selecting conditions for the preparation of medicinal candidates …

Organic thermally activated delayed fluorescence (TADF) compounds used in photocatalysis

MA Bryden, E Zysman-Colman - Chemical Society Reviews, 2021 - pubs.rsc.org
Organic compounds that show Thermally Activated Delayed Fluorescence (TADF) have
become wildly popular as next-generation emitters in organic light emitting diodes (OLEDs) …

Automated self-optimization, intensification, and scale-up of photocatalysis in flow

A Slattery, Z Wen, P Tenblad, J Sanjosé-Orduna… - Science, 2024 - science.org
The optimization, intensification, and scale-up of photochemical processes constitute a
particular challenge in a manufacturing environment geared primarily toward thermal …

Alkyl carbon–carbon bond formation by Nickel/Photoredox cross‐coupling

JA Milligan, JP Phelan, SO Badir… - Angewandte Chemie …, 2019 - Wiley Online Library
The union of photoredox and nickel catalysis has resulted in a renaissance in radical
chemistry as well as in the use of nickel‐catalyzed transformations, specifically for carbon …

Data-science driven autonomous process optimization

M Christensen, LPE Yunker, F Adedeji… - Communications …, 2021 - nature.com
Autonomous process optimization involves the human intervention-free exploration of a
range process parameters to improve responses such as product yield and selectivity …