Genomic centers discover increasingly many protein sequences and structures, but not
necessarily their full biological functions. Thus, currently, less than one percent of proteins …

The evolutionary trace (ET) is the single most validated approach to identify protein
functional determinants and to target mutational analysis, protein engineering and drug …

Protein interactions give rise to networks that control cell fate in health and disease;
selective means to probe these interactions are therefore of wide interest. We discuss here …

Motivation: Predicting protein function is a central problem in bioinformatics, and many
approaches use partially or fully automated methods based on various combination of …

Background Structural genomics projects such as the Protein Structure Initiative (PSI) yield
many new structures, but often these have no known molecular functions. One approach to …

Background For many metalloproteins, sequence motifs characteristic of metal-binding sites
have not been found or are so short that they would not be expected to be metal-specific …

Structural Genomics aims to elucidate protein structures to identify their functions.
Unfortunately, the variation of just a few residues can be enough to alter activity or binding …

Motivation Epitope-based molecular mimicry occurs when an antibody cross-reacts with two
different antigens due to structural and chemical similarities. Molecular mimicry between …

The development of new and effective drugs is strongly affected by the need to identify drug
targets and to reduce side effects. Resolving these issues depends partially on a thorough …

The characterization of biological function among newly determined protein structures is a
central challenge in structural genomics. One class of computational solutions to this …