Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool's gold?

JD Wilson, EM Hammond, GS Higgins… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

Novel therapies for glioblastoma

EK Liu, EP Sulman, PY Wen, SC Kurz - Current Neurology and …, 2020 - Springer
Abstract Purpose of Review Glioblastoma (GBM) is the most common malignant primary
brain tumor, and the available treatment options are limited. This article reviews the recent …

FLASH radiotherapy: A new milestone in the field of cancer radiotherapy

R Tang, J Yin, Y Liu, J Xue - Cancer Letters, 2024 - Elsevier
Radiotherapy plays a pivotal role in the control and eradication of tumors, but it can also
induce radiation injury to surrounding normal tissues while targeting tumor cells. In recent …

First human cell experiments with FLASH carbon ions

M Tashiro, Y Yoshida, T Oike, M Nakao… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: This study aimed to establish a setup for ultra-high-dose-rate (FLASH)
carbon-ion irradiation, and to conduct the first human cell experiments using FLASH carbon …

[HTML][HTML] FLASH Radiotherapy: Benefits, Mechanisms, and Obstacles to Its Clinical Application

L Alhaddad, AN Osipov, S Leonov - International Journal of Molecular …, 2024 - mdpi.com
Radiotherapy (RT) has been shown to be a cornerstone of both palliative and curative tumor
care. RT has generally been reported to be sharply limited by ionizing radiation (IR)-induced …

A mechanistic consideration of oxygen enhancement ratio, oxygen transport and their relevancies for normal tissue sparing under FLASH irradiation

M Jia, X Cao, BW Pogue, H Peng - Holistic Integrative Oncology, 2022 - Springer
Our study investigated the role of oxygen in mediating the FLASH effect. This effect, which
was first reported in vitro in the 1950s and in vivo in the 1970s, recently gained prominence …

Pulse Parameter Optimization Method for Ultra High Dose Rate Electron Treatment

S Jain, A Cetnar, J Woollard, N Gupta, D Blakaj… - arXiv preprint arXiv …, 2023 - arxiv.org
Purpose: Commercial UHDR platforms deliver Ultra-High Dose Rate (UHDR) doses at
discrete combinations of pulse parameters including pulse width (PW), pulse repetition …

[HTML][HTML] A review of the impact of FLASH radiotherapy on the central nervous system and glioma

L Li, Y Yuan, Y Zuo - Radiation Medicine and Protection, 2022 - Elsevier
Glioma has received considerable attention because of its potential of inducing high rates of
morbidity, disability, and mortality. FLASH radiotherapy (FLASH-RT) has emerged as a …