In silico approach in reveal traditional medicine plants pharmacological material basis

F Yi, L Li, L Xu, H Meng, Y Dong, H Liu, P Xiao - Chinese medicine, 2018 - Springer
In recent years, studies of traditional medicinal plants have gradually increased worldwide
because the natural sources and variety of such plants allow them to complement modern …

Critical review on establishment and availability of impurity and degradation product reference standards, challenges faced by the users, recent developments, and …

DK Singh, A Sahu, S Kumar, S Singh - TrAC Trends in Analytical Chemistry, 2018 - Elsevier
The reference standards of impurities (IMPs) and degradation products (DPs) are required
by pharmaceutical industry and quality testing laboratories the world over to comply with …

Characterization of stress degradation products of nintedanib by UPLC, UHPLC-Q-TOF/MS/MS and NMR: Evidence of a degradation product with a structure alert for …

V Dhiman, A Balhara, S Singh, S Tiwari… - … of Pharmaceutical and …, 2021 - Elsevier
Nintedanib is an anti-cancer drug used for the treatment of idiopathic pulmonary fibrosis and
non-small cell lung cancer. The purpose of this study was to explore its degradation …

Study of degradation behaviour of montelukast sodium and its marketed formulation in oxidative and accelerated test conditions and prediction of physicochemical …

SK Tiwari, DK Singh, MK Ladumor… - … of Pharmaceutical and …, 2018 - Elsevier
Study of oxidative stability of pharmaceutical actives and formulations is important as
oxidation pathway is the second most significant route for the decay of pharmaceuticals …

Identification and characterization of urapidil stress degradation products by LC-Q-TOF-MS and NMR: Toxicity prediction of degradation products

L Velip, V Dhiman, BS Kushwah, VM Golla… - … of Pharmaceutical and …, 2022 - Elsevier
Urapidil, an antihypertensive drug is subjected to various stress conditions (acidic, basic,
neutral, oxidative and photolytic) as per ICH guidelines. A stability indicating HPLC method …

Characterization of Degradation Products and Drug–Excipient Interaction Products of Erdafitinib by LC–Q-TOF-MS/MS and NMR

L Velip, V Dhiman, BS Kushwah, G Samanthula - Chromatographia, 2023 - Springer
Erdafitinib is a potent and selective tyrosine kinase receptor inhibitor used to treat advanced
or metastatic urothelial carcinoma. The purpose of this study is to explore the degradation …

Insights into the degradation chemistry of tazarotene, a third generation acetylenic retinoid: LC-HRMS (Orbitrap), LC-MSn and NMR characterization of its degradation …

DK Singh, A Sahu, A Balhara, S Giri, S Singh - Journal of Pharmaceutical …, 2020 - Elsevier
Tazarotene is a prodrug that belongs to the acetylenic class of retinoids. The drug was
subjected to hydrolytic, oxidative and photolytic stress testing to establish its comprehensive …

Forced degradation studies on axitinib and characterization of its degradation products by liquid chromatography‐high resolution mass spectrometry and nuclear …

BS Kushwah, VM Golla, V Dhiman… - Separation Science …, 2022 - Wiley Online Library
The prime focus of the present study includes forced degradation studies on axitinib and the
characterization of novel degradation products formed. As per International Council for …

Comprehensive degradation profiling and influence of different oxidizing reagents on tinoridine hydrochloride: Structural characterization of its degradation products …

V Dhiman, K Patil, L Velip, MVNK Talluri… - Rapid …, 2022 - Wiley Online Library
Rationale Stress testing on tinoridine hydrochloride was carried out using a
multidimensional approach. This included different conditions: hydrolytic (acidic, alkaline …

Isolation, structure elucidation, and high‐performance liquid chromatography quantification of photolytic degradation impurities in acrivastine

JJ Lv, J Yu, XY Zeng, X Zeng, Y Li… - Journal of Separation …, 2022 - Wiley Online Library
Acrivastine is a second‐generation H1‐receptor antagonist, and its structure is sensitive to
ultraviolet. Four unknown and one reported degradation products can be detected in the …