Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer's disease

R Dhapola, P Sarma, B Medhi, A Prakash… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder which leads to mental
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …

Mitochondrial dynamics: a key role in neurodegeneration and a potential target for neurodegenerative disease

D Yang, J Ying, X Wang, T Zhao, S Yoon… - Frontiers in …, 2021 - frontiersin.org
In neurodegenerative diseases, neurodegeneration has been related to several
mitochondrial dynamics imbalances such as excessive fragmentation of mitochondria …

[图书][B] Neurodegeneration: Diagnosis, prevention, and therapy

MK Poddar, A Chakraborty, S Banerjee - 2021 - books.google.com
Neurodegenerative disorders (NDDs) are a broad range of pathological conditions which
target the neurons, creating problems in movements and mental functions. The NDDs have …

Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system

P Hrelia, G Sita, M Ziche, E Ristori… - Oxidative Medicine …, 2020 - Wiley Online Library
Neurodegenerative disease is an umbrella term for different conditions which primarily affect
the neurons in the human brain. In the last century, significant research has been focused on …

A review of ApoE4 interference targeting Mitophagy molecular pathways for Alzheimer's disease

H Chen, F Chen, Y Jiang, L Zhang, G Hu… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is one of the major worldwide causes of dementia that is
characterized by irreversible decline in learning, memory loss, and behavioral impairments …

Effect of tau protein on mitochondrial functions

KK Epremyan, TN Goleva, RA Zvyagilskaya - Biochemistry (Moscow), 2022 - Springer
Alzheimer's disease is the most common age-related progressive neurodegenerative
disorder of brain cortex and hippocampus leading to cognitive impairment. Accumulation of …

α‐Synuclein E46K Mutation and Involvement of Oxidative Stress in a Drosophila Model of Parkinson's Disease

S Reiszadeh Jahromi, SR Ramesh… - Parkinson's …, 2021 - Wiley Online Library
Parkinson's disease (PD) is an age‐associated neurodegenerative condition in which some
genetic variants are known to increase disease susceptibility on interaction with …

The Contribution of Hippocampal All-Trans Retinoic Acid (ATRA) Deficiency to Alzheimer's Disease: A Narrative Overview of ATRA-Dependent Gene Expression in …

J Almaguer, A Hindle, JJ Lawrence - Antioxidants, 2023 - mdpi.com
There is accumulating evidence that vitamin A (VA) deficiency contributes to the
pathogenesis and progression of Alzheimer's disease (AD). All-trans retinoic acid (ATRA), a …

Mitochondria in Alzheimer's disease pathogenesis

AB Reiss, S Gulkarov, B Jacob, A Srivastava… - Life, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder that
primarily affects persons aged 65 years and above. It causes dementia with memory loss …

The deficits of insulin signal in Alzheimer's disease and the mechanisms of vanadium compounds in curing AD

J Yao, Z He, G You, Q Liu, N Li - Current Issues in Molecular Biology, 2023 - mdpi.com
Vanadium is a well-known essential trace element, which usually exists in oxidation states in
the form of a vanadate cation intracellularly. The pharmacological study of vanadium began …