Redox-sensitive nanoscale drug delivery systems for cancer treatment
Pharmaceutical nanotechnology introduces novel strategies in designing smart nanoscale
drug delivery systems (NDDSs) capable of responding to specific conditions. These smart …
drug delivery systems (NDDSs) capable of responding to specific conditions. These smart …
Antioxidant potential of psychotropic drugs: From clinical evidence to in vitro and in vivo assessment and toward a new challenge for in silico molecular design
Due to high oxygen consumption, the brain is particularly vulnerable to oxidative stress,
which is considered an important element in the etiopathogenesis of several mental …
which is considered an important element in the etiopathogenesis of several mental …
Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)
FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …
Low-dose X-ray-responsive diselenide nanocarriers for effective delivery of anticancer agents
X-ray-responsive nanocarriers for anticancer drug delivery have shown great promise for
enhancing the efficacy of chemoradiotherapy. A critical challenge remains for development …
enhancing the efficacy of chemoradiotherapy. A critical challenge remains for development …
Voyage of selenium from environment to life: Beneficial or toxic?
Selenium (Se), a naturally occurring metalloid, is an essential micronutrient for life as it is
incorporated as selenocysteine in proteins. Although beneficial at low doses, Se is …
incorporated as selenocysteine in proteins. Although beneficial at low doses, Se is …
Major depressive disorder and oxidative stress: in silico investigation of fluoxetine activity against ROS
C Muraro, M Dalla Tiezza, C Pavan, G Ribaudo… - Applied Sciences, 2019 - mdpi.com
Featured Application Due to the seriousness of depressive disorders and their social
implications, any strategy to improve clinical symptoms are of considerable importance. It is …
implications, any strategy to improve clinical symptoms are of considerable importance. It is …
Effect of methylmercury binding on the peroxide-reducing potential of cysteine and selenocysteine
A Madabeni, PA Nogara, M Bortoli, JBT Rocha… - Inorganic …, 2021 - ACS Publications
Methylmercury (CH3Hg+) binding to catalytically fundamental cysteine and selenocysteine
of peroxide-reducing enzymes has long been postulated as the origin of its toxicological …
of peroxide-reducing enzymes has long been postulated as the origin of its toxicological …
Methylmercury can facilitate the formation of dehydroalanine in selenoenzymes: Insight from DFT molecular modeling
PA Nogara, A Madabeni, M Bortoli… - Chemical Research …, 2021 - ACS Publications
Experimental studies have indicated that electrophilic mercury forms (eg, methylmercury,
MeHg+) can accelerate the breakage of selenocysteine in vitro. Particularly, in 2009, Khan …
MeHg+) can accelerate the breakage of selenocysteine in vitro. Particularly, in 2009, Khan …
Tuning conductivity and roughness of diselenide polymer dot-coated surface for ROS-mediated selective real-time wireless detection of cancer cells
Reactive oxygen species (ROS)-responsive materials for the selective and sensitive
electrochemical detection of cancer cells have been studied comprehensively, especially …
electrochemical detection of cancer cells have been studied comprehensively, especially …
Proton Transfer and SN2 Reactions as Steps of Fast Selenol and Thiol Oxidation in Proteins: A Model Molecular Study Based on GPx
M Dalla Tiezza, FM Bickelhaupt, L Flohé… - …, 2021 - Wiley Online Library
The so‐called peroxidatic cysteines and selenocysteines in proteins reduce hydroperoxides
through a dual attack to the peroxide bond in a two‐step mechanism. First, a proton …
through a dual attack to the peroxide bond in a two‐step mechanism. First, a proton …