Malaria remains a major world health problem following the emergence and spread of
Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem …

Malaria still poses one of the most serious threats to human health worldwide and the
prevailing lack of effective, clinically licensed, vaccines means that prophylaxis and …

Malaria is still a very serious worldwide public health problem affecting between 300 and
500 million people and causing from 1.0 to 2.5 million deaths annually. The major problems …

Parasitic diseases have a serious impact on the world in terms of health and economics and
are responsible for worldwide mortality and morbidity. The present review features the …

The malaria parasite Plasmodium falciparum depends primarily on nutrient sources from its
human host. Most compounds, such as glucose, purines, amino acids, as well as cofactors …

Target-based approaches toward new antimalarial treatments are highly valuable to prevent
resistance development. We report several series of pyrazolopyran-based inhibitors …

Recently, we reported a library of 82 compounds, selected from different databanks through
virtual screening and docking studies, and pointed to 6 among them as potential repurposed …

As the enzyme nucleoside hydrolase (NH) is widely found in nature but has not yet been
detected in mammals, it is considered an ideal target in the development of chemotherapy …

Anthrax is a disease caused by Bacillus anthracis, a dangerous biological warfare agent
already used for both military and terrorist purposes. An important selective target for …

Abstract Design and discovery of new potential inhibitors of Plasmodium falciparum
dihydrofolate reductase (PfDHFR), equally active against both the wild-type and mutant …