THE MAMMALIAN IMMUNE SYSTEM can be broadly divided into two main arms: innate and
adaptive immunity. As its name implies, the cells and receptors of the innate immune system …

Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

Protective immunity against pathogens depends on the efficient generation of functionally
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …

Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …

Memory T cells are thought to rely on oxidative phosphorylation and short-lived effector T
cells on glycolysis. Here, we investigated how T cells arrive at these states during an …

Memory CD8 T cells provide durable protection against diverse intracellular pathogens and
can be broadly segregated into distinct circulating and tissue-resident populations …

Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to
the relationship between replicative history and the formation of distinct CD8+ memory T cell …

Summary The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of
CD4+ T cells; however, its cell-intrinsic role in CD8+ T cells remains elusive. Herein we …

The CD8+ memory T cell population is heterogeneous, and it is unclear which subset (s)
optimally mediate the central goal of the immune system—protection against infection. Here …

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …