Blobel and coworkers discovered in 1978 that peroxisomal proteins are synthesized on free
ribosomes in the cytosol and thus provided the grounds for the conception of peroxisomes …

Proteins are positioned and act at defined subcellular locations. This is particularly important
in eukaryotic cells that deliver proteins to membrane-bound organelles such as the …

RNAs have been shown to undergo transfer between mammalian cells, although the
mechanism behind this phenomenon and its overall importance to cell physiology is not well …

The formation of stress granules (SGs) is an essential aspect of the cellular response to
many kinds of stress, but its adaptive role is far from clear. SG dysfunction is implicated in …

The type-2 peroxisomal targeting signal (PTS2) is one of two peptide motifs destining
soluble proteins for peroxisomes. This signal acts as amphiphilic α-helix exposing the side …

The peroxisomal membrane protein (PMP) Pex3 and its cytosolic interaction partner Pex19
have been implicated in peroxisomal membrane biogenesis. Although these peroxins have …

Spatial organization of protein biosynthesis in the eukaryotic cell has been studied for more
than fifty years, thus many facts have already been included in textbooks. According to the …

Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by
cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional …

The mechanics of how proteins are generated from mRNA is increasingly well understood.
However, much less is known about how protein production is coordinated and orchestrated …

Peroxisomes are ubiquitous organelles of eukaryotic cells, and it is becoming increasingly
clear that the biogenesis of these multi-purpose organelles is more complex than initially …