[HTML][HTML] MGMT and whole-genome DNA methylation impacts on diagnosis, prognosis and therapy of glioblastoma multiforme
R Della Monica, M Cuomo, M Buonaiuto… - International Journal of …, 2022 - mdpi.com
Epigenetic changes in DNA methylation contribute to the development of many diseases,
including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and …
including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and …
Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy
J Anand, L Chiou, C Sciandra, X Zhang, J Hong… - NAR …, 2023 - academic.oup.com
DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …
[HTML][HTML] A new drug Discovery Platform: application to DNA polymerase eta and Apurinic/Apyrimidinic Endonuclease 1
D Das, MAJ Duncton, TM Georgiadis… - International Journal of …, 2023 - mdpi.com
The ability to quickly discover reliable hits from screening and rapidly convert them into lead
compounds, which can be verified in functional assays, is central to drug discovery. The …
compounds, which can be verified in functional assays, is central to drug discovery. The …
The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis
Human xeroderma pigmentosum variant (XP-V) patients are mutated in the POLH gene,
responsible for encoding the translesion synthesis (TLS) DNA polymerase eta (Pol eta) …
responsible for encoding the translesion synthesis (TLS) DNA polymerase eta (Pol eta) …
Temozolomide resistance mechanisms: unveiling the role of translesion DNA polymerase kappa in glioblastoma spheroids in vitro
DL Ribeiro, MT Latancia, I de Souza… - Bioscience …, 2024 - portlandpress.com
Temozolomide (TMZ) is the leading therapeutic agent for combating Glioblastoma
Multiforme (GBM). Nonetheless, the persistence of chemotherapy-resistant GBM cells …
Multiforme (GBM). Nonetheless, the persistence of chemotherapy-resistant GBM cells …
[HTML][HTML] Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.
MT Latancia, G da Silva Leandro, AU Bastos… - DNA repair, 2024 - Elsevier
Glioblastoma (GBM) is a highly aggressive brain tumor associated with poor patient survival.
The current standard treatment involves invasive surgery, radiotherapy, and chemotherapy …
The current standard treatment involves invasive surgery, radiotherapy, and chemotherapy …
DNA mismatch repair controls the mutagenicity of Polymerase ζ-dependent translesion synthesis at methylated guanines
A Tsaalbi-Shtylik, C Mingard, M Räz, R Oka, F Manders… - DNA Repair, 2024 - Elsevier
By replicating damaged nucleotides, error-prone DNA translesion synthesis (TLS) enables
the completion of replication, albeit at the expense of fidelity. TLS of helix-distorting DNA …
the completion of replication, albeit at the expense of fidelity. TLS of helix-distorting DNA …
[PDF][PDF] Critical Reviews and Perspectives Roles of trans-lesion synthesis TLS DNA polymerases in tumorigenesis and cancer therapy
J Anand, L Chiou, C Sciandra, X Zhang, J Hong, D Wu… - dukespace.lib.duke.edu
ABSTRACT DNA damage tolerance and mutagenesis are hallmarks and enabling
characteristics of neoplastic cells that drive tumorigenesis and allow cancer cells to resist …
characteristics of neoplastic cells that drive tumorigenesis and allow cancer cells to resist …