Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 … - Nature, 2021 - nature.com
The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …
infection. Although environmental, clinical and social factors have a role in the chance of …
Type I interferons in COVID-19 pathogenesis
Simple Summary The innate antiviral immune response is essential to limit virus replication
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …
Genetic associations of protein-coding variants in human disease
Genome-wide association studies (GWAS) have identified thousands of genetic variants
linked to the risk of human disease. However, GWAS have so far remained largely …
linked to the risk of human disease. However, GWAS have so far remained largely …
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
JA Kosmicki, JE Horowitz, N Banerjee, R Lanche… - The American Journal of …, 2021 - cell.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …
Genetic map of regional sulcal morphology in the human brain from UK biobank data
Genetic associations with macroscopic brain structure can provide insights into brain
function and disease. However, specific associations with measures of local brain folding …
function and disease. However, specific associations with measures of local brain folding …
Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity
The determinants of severe COVID-19 in healthy adults are poorly understood, which limits
the opportunity for early intervention. We present a multiomic analysis using machine …
the opportunity for early intervention. We present a multiomic analysis using machine …
COVID-19 severity: does the genetic landscape of rare variants matter?
MB Khadzhieva, AS Gracheva, OB Belopolskaya… - Frontiers in …, 2023 - frontiersin.org
Rare variants affecting host defense against pathogens may be involved in COVID-19
severity, but most rare variants are not expected to have a major impact on the course of …
severity, but most rare variants are not expected to have a major impact on the course of …
Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration
A Guvenek, N Parikshak, D Zamolodchikov… - Communications …, 2024 - nature.com
Microglia are the resident immune cells of the central nervous system and are involved in
brain development, homeostasis, and disease. New imaging and genomics technologies …
brain development, homeostasis, and disease. New imaging and genomics technologies …
COVID-19 in pediatrics: Genetic susceptibility
The uptick in SARS-CoV-2 infection has resulted in a worldwide COVID-19 pandemic, which
has created troublesome health and economic problems. We performed case–control meta …
has created troublesome health and economic problems. We performed case–control meta …