11q deletion in neuroblastoma: a review of biological and clinical implications
V Mlakar, S Jurkovic Mlakar, G Lopez, JM Maris… - Molecular cancer, 2017 - Springer
Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …
Neuroblastoma treatment in the post-genomic era
Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest
cells and showing heterogeneous biological, morphological, genetic and clinical …
cells and showing heterogeneous biological, morphological, genetic and clinical …
[HTML][HTML] Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical …
H Hanson, E Astiazaran-Symonds, LM Amendola… - Genetics in …, 2023 - Elsevier
Purpose Although the role of CHEK2 germline pathogenic variants in cancer predisposition
is well known, resources for managing CHEK2 heterozygotes in clinical practice are limited …
is well known, resources for managing CHEK2 heterozygotes in clinical practice are limited …
Genetic predisposition and chromosome instability in neuroblastoma
Neuroblastoma (NB) is a pediatric tumor of embryonic origin. About 1–2% of all NBs are
familial cases, and genetic predisposition is suspected for the remaining cases. During the …
familial cases, and genetic predisposition is suspected for the remaining cases. During the …
HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
F Cimmino, M Avitabile, VA Lasorsa, A Montella… - BMC medical …, 2019 - Springer
Abstract Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is
relevant to establish resistance to therapeutic approaches. The use of compounds direct …
relevant to establish resistance to therapeutic approaches. The use of compounds direct …
Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival
Background Neuroblastoma is an embryonal cancer of the developing sympathetic nervous
system. The genetic contribution of rare pathogenic or likely pathogenic germline variants in …
system. The genetic contribution of rare pathogenic or likely pathogenic germline variants in …
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease
A Alendar, A Berns - Genes & Development, 2021 - genesdev.cshlp.org
Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …
type of histone and DNA modifications governed by processes such as transcription, repair …
BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma
Background High-risk neuroblastoma is a complex genetic disease that is lethal in more
than 50% of patients despite intense multimodal therapy. Through genome-wide association …
than 50% of patients despite intense multimodal therapy. Through genome-wide association …
Genetic predisposition to solid pediatric cancers
M Capasso, A Montella, M Tirelli, T Maiorino… - Frontiers in …, 2020 - frontiersin.org
Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …
scale analyses—including high-density genotyping and exome and genome sequencing …
Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …
immunotherapeutic methods. In particular, the present invention relates to the immuno …