ABSTRACT MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …

To evaluate the contribution of candidate gene association studies to the understanding of
genetic susceptibility to childhood acute lymphoblastic leukemia we conducted a systematic …

Abstract Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux
pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P …

Transporters are divided into the ABC and SLC super-families, mediating the cellular efflux
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …

Background P-glycoprotein, the product of the MDR1 gene, is a transmembrane active efflux
pump for a variety of environmental toxins and xenobiotics. Epidemiological studies have …

Background: MDR1, one of the most important drug-transporter genes, encodes P-
glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug …

Background The multidrug resistance (MDR) 1 gene encodes a 170-kDa membrane
transporter called P-glycoprotein, which plays an important role in protecting cells against …

We aimed to explore the possible influence of CYP2C9 (* 2,* 3 and IVS8-109 A> T),
CYP2C19 (* 2,* 3 and* 17) and ABCB1 (1236C> T, 2677G> A/T and 3435C> T) on …

Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by
interactions between hazardous exogenous or/and endogenous agents and many mild …

Background: P-glycoprotein (P-gp), a membrane transporter encoded by the multidrug
resistance-1 (MDR1) gene, influences pharmacokinetics and metabolism of anticancer …