The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Biologists have long appreciated the critical role that energy turnover plays in understanding
variation in performance and fitness among individuals. Whole-organism metabolic studies …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart
failure, and other cardiovascular diseases, as well, but no therapies are available to treat …

The pathophysiology, immune reaction, and differential vulnerability of different population
groups and viral host immune system evasion strategies of severe acute respiratory …

Background Frailty is associated with numerous post‐operative adverse outcomes in older
adults. Current pre‐operative frailty screening tools require additional data collection or …

Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more
severe and less responsive to treatment in obese subjects. While alterations in …

Mitochondria operate as hubs of cellular metabolism that execute important regulatory
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …

It is now becoming clear that human metabolism is extremely plastic and varies substantially
between healthy individuals. Understanding the biochemistry that underlies this physiology …