[HTML][HTML] The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment

A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Mitochondrial oxidative phosphorylation system (OXPHOS) deficits in schizophrenia: possible interactions with cellular processes

O Bergman, D Ben-Shachar - The Canadian Journal of …, 2016 - journals.sagepub.com
Mitochondria are key players in the generation and regulation of cellular bioenergetics,
producing the majority of adenosine triphosphate molecules by the oxidative …

[HTML][HTML] Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits

AK Kanellopoulos, V Mariano, M Spinazzi, YJ Woo… - Cell, 2020 - cell.com
Social impairment is frequently associated with mitochondrial dysfunction and altered
neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it …

Retinal layer abnormalities as biomarkers of schizophrenia

NN Samani, FA Proudlock, V Siram… - Schizophrenia …, 2018 - academic.oup.com
Objective Schizophrenia is associated with several brain deficits, as well as visual
processing deficits, but clinically useful biomarkers are elusive. We hypothesized that retinal …

Mitochondrial multifaceted dysfunction in schizophrenia; complex I as a possible pathological target

D Ben-Shachar - Schizophrenia research, 2017 - Elsevier
Mitochondria are key players in various essential cellular processes beyond being the main
energy supplier of the cell. Accordingly, they are involved in neuronal synaptic transmission …

[HTML][HTML] Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

T Santos-Silva, D Hazar Ülgen, CFB Lopes… - Translational …, 2023 - nature.com
Adolescent individuals exhibit great variability in cortical dynamics and behavioral
outcomes. The developing adolescent brain is highly sensitive to social experiences and …

[HTML][HTML] Genetic relationship between schizophrenia and nicotine dependence

J Chen, SA Bacanu, H Yu, Z Zhao, P Jia, KS Kendler… - Scientific reports, 2016 - nature.com
It is well known that most schizophrenia patients smoke cigarettes. There are different
hypotheses postulating the underlying mechanisms of this comorbidity. We used summary …

[HTML][HTML] The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets

SG Lago, S Bahn - NPJ genomic medicine, 2022 - nature.com
There have been no new drugs for the treatment of schizophrenia in several decades and
treatment resistance represents a major unmet clinical need. The drugs that exist are based …

[HTML][HTML] The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia diagnosis and treatment …

S Liu, F Zhang, YY Shugart, L Yang, X Li, Z Liu… - Translational …, 2017 - nature.com
To date, diagnosis of schizophrenia is still based on clinical interviews and careful
observations, which is subjective and variable, and can lead to misdiagnosis and/or delay in …

Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure

AK Machado, AC Andreazza… - Oxidative medicine …, 2016 - Wiley Online Library
Neuropsychiatric diseases, such as bipolar disorder (BD) and schizophrenia (SCZ), have a
very complex pathophysiology. Several current studies describe an association between …