Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

The success of a primary percutaneous intervention (PCI) in the setting of ST elevation
myocardial infarction depends on the functional and structural integrity of coronary …

Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …

The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …

Acute myocardial infarction (AMI) with subsequent left ventricular dysfunction and heart
failure continues to be a major cause of morbidity and mortality in the Western world. Rapid …

Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …