Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate
gene expression and are involved in cancer pathogenesis. Over the last years, several BET …

BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …

Lysine (Lys) residues in proteins undergo a wide range of reversible post-translational
modifications (PTMs), which can regulate enzyme activities, chromatin structure, protein …

Despite the ability of combination antiretroviral therapy (cART) to increase the life
expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs …

Background: During the past 35 years, highly effective ART has saved the lives of millions of
people worldwide by suppressing viruses to undetectable levels. However, this does not …

In this study, we investigated the effects of the dual phosphatidylinositol 3-
kinase/mechanistic target of rapamycin (PI3K/MTOR) inhibitor dactolisib (NVP-BEZ235), the …

Transcriptional programs in embryogenesis and cancer, such as the epithelial-to-
mesenchymal transition (EMT), ensure cellular plasticity, an essential feature of carcinoma …