RNA is arguably the most versatile biological macromolecule because of its ability both to
encode and to manipulate genetic information. The diverse roles of RNA depend on its …

Multivalent polyions can undergo complex coacervation, producing membraneless
compartments that accumulate ribozymes and enhance catalysis, and offering a mechanism …

Given that greater than 90% of the human genome is expressed, it is logical to assume that
post-transcriptional regulatory mechanisms must be the primary means of controlling the …

Regulation of translation initiation is well appropriate to adapt cell growth in response to
stress and environmental changes. Many bacterial mRNAs adopt structures in their 5 …

Guanine-rich RNA sequences can fold into non-canonical, four stranded helical structures
called G-quadruplexes that have been shown to be widely distributed within the mammalian …

Telomerase reverse transcribes short guanine (G)-rich DNA repeat sequences from its
internal RNA template to maintain telomere length. G-rich telomere DNA repeats readily fold …

Isothermal titration calorimetry (ITC) is the method of choice for obtaining thermodynamic
data on a great variety of systems. Here we show that modern ITC apparatus and new …

RNA structure plays important roles in diverse biological processes. However, the structures
of all but the few most abundant RNAs are presently unknown in vivo. Here we introduce …

Most RNA folding studies have been performed under non-physiological conditions of high
concentrations (≥ 10 mM) of Mg2+ free, while actual cellular concentrations of Mg2+ free …

Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with the liver-specific
microRNA, miR-122. miR-122 binds to two sites in the 5′ untranslated region (UTR) and …