Mesenchymal tumours represent one of the most challenging field of diagnostic pathology
and refinement of classification schemes plays a key role in improving the quality of …

Soft tissue tumors are a relatively rare and diagnostically challenging group of neoplasms
that can have varying lines of differentiation. Accurate diagnosis is important for appropriate …

The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and
Bone was published in early 2020. The revisions reflect a consensus among an …

Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The
diversity and considerable morphologic overlap of bone tumors with other mesenchymal …

The fourth edition of the World Health Organization (WHO) Classification of Tumours of Soft
Tissue and Bone was published in February 2013, and serves to provide an updated …

CIC-DUX4 gene fusion, resulting from either at (4; 19) or t (10; 19) translocation, is the most
common genetic abnormality detected in EWSR1-negative small blue round cell tumors …

The new W orld H ealth O rganization (WHO) classification of soft tissue tumours was
published in early 2013, almost 11 years after the previous edition. While the number of …

Chromosomal rearrangements deregulating hematopoietic transcription factors are common
in acute lymphoblastic leukemia (ALL). Here we show that deregulation of the homeobox …

Ewing sarcoma (ES) and Ewing-like sarcomas are highly aggressive round cell
mesenchymal neoplasms, most often occurring in children and young adults. The …

The 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone
incorporates changes in tumor classification, as well as new genetic insights into the …