Circulating tumor DNA in biliary tract cancer: current evidence and future perspectives

A Rizzo, AD Ricci, S Tavolari… - Cancer genomics & …, 2020 - cgp.iiarjournals.org
Peripheral blood of cancer patients “physiologically” presents cells and cellular components
deriving from primary or metastatic sites, including circulating tumor cells (CTCs), circulating …

Second-line therapies in advanced biliary tract cancers

SH Tella, A Kommalapati, MJ Borad… - The Lancet …, 2020 - thelancet.com
Biliary tract cancers constitute approximately 3% of gastrointestinal malignancies with poor
prognosis. Surgical therapy is the main form of treatment in localised disease; however, for …

Phase I study of chimeric antigen receptor–modified T cells in patients with EGFR-positive advanced biliary tract cancers

Y Guo, K Feng, Y Liu, Z Wu, H Dai, Q Yang… - Clinical Cancer …, 2018 - AACR
Purpose: This study is an expanded and parallel clinical trial of EGFR-specific chimeric
antigen receptor–engineered autologous T (CART) cell immunotherapy (NCT01869166) to …

Cholangiocarcinoma

M Squadroni, L Tondulli, G Gatta, S Mosconi… - Critical reviews in …, 2017 - Elsevier
Biliary tract cancer accounts for< 1% of all cancers and affects chiefly an elderly population,
with predominance in men. We distinguish cholangiocarcinoma (intrahepatic, hilar and …

Medical treatment for cholangiocarcinoma

J Adeva, B Sangro, M Salati, J Edeline… - Liver …, 2019 - Wiley Online Library
Most of the patients with cholangiocarcinoma (CCA) present with advanced (inoperable or
metastatic) disease, and relapse rates are high in those undergoing potentially curative …

Italian clinical practice guidelines on cholangiocarcinoma–Part II: treatment

D Alvaro, C Hassan, V Cardinale, G Carpino… - Digestive and Liver …, 2020 - Elsevier
Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection,
though this treatment is possible in less than 40% of patients. However, recent …

Second‐line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine‐platinum combination: A large multicenter study by the Association des …

B Brieau, L Dahan, Y De Rycke, T Boussaha… - Cancer, 2015 - Wiley Online Library
BACKGROUND Few data are available on second‐line chemotherapy (CT2) for advanced
biliary tract cancer (ABTC). The aim of this multicenter study was to describe the CT2 …

[HTML][HTML] Precision medicine in cholangiocarcinoma

A Pellino, F Loupakis, M Cadamuro… - Translational …, 2018 - ncbi.nlm.nih.gov
Cholangiocarcinoma is one of the epithelial cancers with the poorest prognosis and the
narrowest therapeutic choice in humans. Compared with other cancer types …

[HTML][HTML] Prognostic factors for progression-free and overall survival in advanced biliary tract cancer

J Bridgewater, A Lopes, H Wasan, D Malka, L Jensen… - Annals of …, 2016 - Elsevier
Background Biliary tract cancer is an uncommon cancer with a poor outcome. We
assembled data from the National Cancer Research Institute (UK) ABC-02 study and 10 …

[HTML][HTML] Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies

G Brandi, A Farioli, A Astolfi, G Biasco, S Tavolari - Oncotarget, 2015 - ncbi.nlm.nih.gov
Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies - PMC
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