Nanobody: a promising toolkit for molecular imaging and disease therapy

G Bao, M Tang, J Zhao, X Zhu - EJNMMI research, 2021 - Springer
Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with
many unique properties such as small size, excellent solubility, superior stability, quick …

PSMA-targeted radiopharmaceuticals for imaging and therapy

HJ Wester, M Schottelius - Seminars in nuclear medicine, 2019 - Elsevier
As described in more detail in other contributions in this issue of Seminars in Nuclear
Medicine, prostate-specific membrane antigen (PSMA) has become one of the most …

[HTML][HTML] Advances in PSMA theranostics

TM Jeitner, JW Babich, JM Kelly - Translational Oncology, 2022 - Elsevier
The validation of prostate specific membrane antigen (PSMA) as a molecular target in
metastatic castration-resistant prostate cancer has stimulated the development of multiple …

The future of PSMA-targeted radionuclide therapy: an overview of recent preclinical research

EAM Ruigrok, WM van Weerden, J Nonnekens… - Pharmaceutics, 2019 - mdpi.com
Prostate specific membrane antigen (PSMA) has become a major focus point in the research
and development of prostate cancer (PCa) imaging and therapeutic strategies using …

177Lu-labeled albumin-binder–conjugated PSMA-targeting agents with extremely high tumor uptake and enhanced tumor-to-kidney absorbed dose ratio

HT Kuo, KS Lin, Z Zhang, CF Uribe… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The use of an albumin binder has been shown to improve tumor uptake of prostate-specific
membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to …

Development of [177Lu]Lu-LNC1003 for radioligand therapy of prostate cancer with a moderate level of PSMA expression

X Wen, P Xu, X Zeng, J Liu, C Du, X Zeng… - European Journal of …, 2023 - Springer
Purpose Evans blue as an albumin binder has been widely used to improve
pharmacokinetics and enhance tumor uptake of radioligands, including prostate-specific …

Global experience with PSMA-based alpha therapy in prostate cancer

MM Sathekge, F Bruchertseifer, M Vorster… - European Journal of …, 2021 - Springer
Purpose This review discusses the current state of prostate-specific membrane antigen
(PSMA)-based alpha therapy of metastatic castration-resistant prostate cancer (mCRPC) …

Salivary Gland Toxicity of PSMA-Targeted Radioligand Therapy with 177Lu-PSMA and Combined 225Ac- and 177Lu-Labeled PSMA Ligands (TANDEM-PRLT) in …

T Langbein, HR Kulkarni, C Schuchardt, D Mueller… - Diagnostics, 2022 - mdpi.com
Purpose: PSMA-targeted radioligand therapy (PRLT) is a promising treatment option for
patients with metastatic castration-resistant prostate cancer (mCRPC). However, a high …

Lutetium-177 prostate-specific membrane antigen (PSMA) theranostics: practical nuances and intricacies

A Iravani, J Violet, A Azad, MS Hofman - Prostate cancer and prostatic …, 2020 - nature.com
Theranostic principles utilize a molecular biomarker specific for a tumor target, initially for
imaging to assess target expression and, if deemed suitable, for targeted therapy. This …

A Review on the Current State and Future Perspectives of [99mTc]Tc-Housed PSMA-i in Prostate Cancer

S Brunello, N Salvarese, D Carpanese, C Gobbi… - Molecules, 2022 - mdpi.com
Recently, prostate-specific membrane antigen (PSMA) has gained momentum in tumor
nuclear molecular imaging as an excellent target for both the diagnosis and therapy of …