Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance,.
Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating …

Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …

A high-fat diet (HFD) is linked with cytokines production by non-neuronal cells within the
hypothalamus, which mediates metabolic inflammation. These cytokines then activate …

Hypothalamic inflammation plays an important role in disrupting feeding behavior and
energy homeostasis as well as in the pathogenesis of obesity and diabetes. Here, we show …

The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over
the years, studies on energy metabolism primarily focused on the neuronal component of …

Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes
adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of …

The global prevalence of obesity has been steadily increasing. Although pharmacotherapy
and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may …